Dr. Wang has broad basic science trainings and experience in vascular cell and molecular biology, nitrite/nitric oxide signaling pathway, redox biology, mitochondrial function and various preclinical animal models. Dr. Wang started collaboration with Dr. Li from 2015 on the pathogenesis of muscle/bone comorbidity in DMD when she was a junior research faculty in Vascular Medicine Institute, University of Pittsburgh. They identified significantly altered expression of several bone-regulating myokines in DMD animal models, and further demonstrated that muscle-derived FGF21 negatively regulates bone homeostasis and may represent a novel therapeutic target in DMD (JBMR 2019). In July 2021, Dr. Wang joined Dr. Li’s new lab in the University of Iowa as a Research Assistant Professor to further investigate the pathological roles of FGF21 in the pathogenesis of muscle and bone comorbidity in DMD. Dr. Wang's other research interest includes understanding the role of vascular endothelial cells in muscular skeletal disease. Dr. Wang has served as co-investigator on several NIH and other grants including Dr. Li’s current R01. 

Selected Publications:

1. Wang L* (corresponding author), Rochon ER, Gingras S, Zuchelkowski B, Sinchar DJ, Alipour E, Reisz JA, Yang M, Page G, Kanias T, Triulzi D, Lee JS, Kim-Shapiro DB, D’Alessandro A, Gladwin MT*. Functional effects of an African glucose-6-phosphate dehydrogenase (G6PD) polymorphism (Val68Met) on RBC hemolytic propensity and post-transfusion recovery. Transfusion. 2024 Feb 23. doi: 10.1111/trf.17756. Epub ahead of print. PMID: 38400625.
2. Xu Q, Rose JJ, Chen X, Wang L, DeMartino AW, Dent MR, Tiwari S, Bocian K, Huang XN, Tong Q, McTiernan CF, Guo L, Alipour E, Jones TC, Ucer KB, Kim-Shapiro DB, Tejero J, Gladwin MT. Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning. JCI Insight. 2022 Nov 8;7(21):e153296. doi: 10.1172/jci.insight.153296. PMID: 36173682. PMCID: PMC9675481
3. Wang L*, Sparacino-Watkins CE*, Wang J, Wajih N, Varano P, Xu Q, Cecco E, Tejero J, Soleimani M, Kim-Shapiro DB, Gladwin MT. Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation. Br J Pharmacol. 2020 Feb;177(4):898-911. doi: 10.1111/bph.14887. PMID: 31658361. PMCID: PMC7024708. (*corresponding author)
4. Li H, Sun H, Qian B, Feng W, Carney D, Miller J, Hogan MV, Wang L. Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice. J Bone Miner Res. 2020 Apr;35(4):738-752. doi: 10.1002/jbmr.3932. PMID: 31800971.
5. Zuchelkowski BE, Wang L, Gingras S, Xu Q, Yang M, Triulzi D, Page GP, Gordeuk VR, Kim-Shapiro DB, Lee JS, Gladwin MT. Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage in a "humanized" G6PD A- mouse model. PLoS One. 2020;15(10):e0240266. doi: 10.1371/journal.pone.0240266. PMID: 33007039. PMCID: PMC7531777.
6. Zhou S, Qian B, Wang L, Zhang C, Hogan MV, Li H. Altered bone-regulating myokine expression in skeletal muscle Of Duchenne muscular dystrophy mouse models. Muscle Nerve. 2018 Oct;58(4):573-582. doi: 10.1002/mus.26195. PMID: 30028902.
7. Azarov I*, Wang L* , Rose JJ*, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016 Dec 7;8(368):368ra173. doi: 10.1126/scitranslmed.aah6571. PMID: 27928027. PMCID: PMC5206801. (*co-first author)
8. Zhao XJ, Wang L, Shiva S, Tejero J, Myerburg MM, Wang J, Frizzell S, Gladwin MT. Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells. Free Radic Biol Med. 2013;61:428-37. doi: 10.1016/j.freeradbiomed.2013.04.031. PMID: 23639566. PMCID: PMC3883890. 
9. Wang L, Frizzell SA, Zhao X, Gladwin MT. Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitric Oxide. 2012 May 15;26(4):203-10. doi: 10.1016/j.niox.2012.03.002. PMID: 22425780. PMCID: PMC3854970.
10. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr;36(4):497-503. doi: 10.1165/rcmb.2005-0425OC. PMID: 17099142. PMCID: PMC1899324.

Complete List of Published Work:

 https://www.ncbi.nlm.nih.gov/myncbi/1nIafLAKlWNkB/bibliography/public/